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Zhen-Jia Zhang,Qiang Gao,Xiao-Dong Fang,Yi-Zhou Yang,Chenggui Han,Ying Wang,Xuefeng Yuan,Dawei Li,Xian-Bing Wang.CCR4, a RNA Decay Factor, Is Hijacked by a Plant Cytorhabdovirus Phosphoprotein to Facilitate Virus Replication.DOI: 10.7554/eLife.53753
发布日期: 2019-04-28 浏览次数:   信息来源:ag视讯_Ag视讯官网-「开户首充送大礼」

CCR4, a RNA Decay Factor, Is Hijacked by a Plant Cytorhabdovirus Phosphoprotein to Facilitate Virus Replication

ag视讯zhen-jia zhang,qiang gao,xiao-dong fang,zhi-hang ding,dong-min gao,wen-ya xu,qing cao,ji-hui qiao,yi-zhou yang,chenggui han,ying wang,xuefeng yuan,dawei li,xian-bing wang


Elife

DOI: 10.7554/eLife.53753



Abstract

carbon catabolite repression 4 (ccr4) is a conserved mrna deadenylase regulating posttranscriptional gene expression. however, regulation of ccr4 in virus infections is less understood. here, we characterized a pro-viral role of ccr4 in replication of a plant cytorhabdovirus, barley yellow striate mosaic virus (bysmv). the barley (hordeum vulgare) ccr4 protein (hvccr4) was identified to interact with the bysmv phosphoprotein (p). the bysmv p protein recruited hvccr4 from processing bodies (pbs) into viroplasm-like bodies. overexpression of hvccr4 promoted bysmv replication in plants. conversely, knockdown of the small brown planthopper ccr4 inhibited viral accumulation in the insect vector. biochemistry experiments revealed that hvccr4 was recruited into n-rna complexes by the bysmv p protein and triggered turnover of n-bound cellular mrnas, thereby releasing rna-free n protein to bind viral genomic rna for optimal viral replication. our results demonstrate that the co-opted ccr4-mediated rna decay facilitates cytorhabdovirus replication in plants and insects.


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